NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (7): 1170-1175.doi: 10.16333/j.1001-6880.2018.7.013

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Isolation,Identification and Antimicrobial Activity of Secondary Metabolites from a Soil-derived Streptomyces sp.L8 of Qinghaihu

WANG Yong-jiang1,3,HE Xin2,3,LUO Jian-ying3,XIONG Zi-jun3,HUANG Jian-ping3,MA Ya-tuan3,HUANG Sheng-xiong1,3*,ZHU Yan-ling2*   

  1. 1School of Chemical Science and Technology,Yunnan University,Kunming 650091,China; 2Haiyuan College of Kunming Medical University,Yunnan Kunming 650106,China; 3State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Yunnan Kunming 650201,China  
  • Online:2018-08-08 Published:2018-08-08

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Abstract: Seven compounds were isolated from a soil-derived Streptomyces sp.L8 of Qinghaihu by silica gel column,Sephadex LH-20 chromatography and semi-preparative HPLC.Their structures were identified as Germicidin B (1),Germicidin A (2),1-Acetyl-β-carboline (3),N-Isobutylacetamide (4),cyclo-(1-Pro-1-Val) (5),cyclo-(1-Pro-1-Phe) (6) and 3-Hydroxy-3-(2-Hydroxyethyl)-6-(3-Methylbut-2-en-1-yl)indolin-2-one (7) by NMR and mass spectrometry and 7 was a new compound.Among them,compound 3 displayed weak inhibitory activity against Staphylococcus aureus and compound 4 showed weak antifungal activity against Curvularia lunata (Walk) Boed.

Key words: Streptomyces, secondary metabolites, structure identification, antimicrobial activity

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