NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (7): 1176-1180. doi: 10.16333/j.1001-6880.2018.7.014

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Secondary Metabolites of Endophytic Daldinia eschscholtzii A630 from Pogostemon cablin and Their Cytotoxic Activities

LU Meng-meng1,2,CHEN Yu-chan1,LIU Hong-xin1,LI Sai-ni1,LI Hao-hua1,TAO Mei-hua1,HAO Zai-bin2,ZHANG Wei-min1*   

  1. 1State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China; 2College of Chemistry and Bioengineering,Guilin University of Technology, Guilin 541006, China
  • Online:2018-08-08 Published:2018-08-08

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Abstract: Seven compounds were isolated from a soil-derived Streptomyces sp.L8 of Qinghaihu by silica gel column,Sephadex LH-20 chromatography and semi-preparative HPLC.Their structures were identified as Germicidin B (1),Germicidin A (2),1-Acetyl-β-carboline (3),N-Isobutylacetamide (4),cyclo-(1-Pro-1-Val) (5),cyclo-(1-Pro-1-Phe) (6) and 3-Hydroxy-3-(2-Hydroxyethyl)-6-(3-Methylbut-2-en-1-yl)indolin-2-one (7) by NMR and mass spectrometry and 7 was a new compound.Among them,compound 3 displayed weak inhibitory activity against Staphylococcus aureus and compound 4 showed weak antifungal activity against Curvularia lunata (Walk) Boed.

Key words: Streptomyces, secondary metabolites, structure identification, antimicrobial activity

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