NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (8): 1354-1360. doi: 10.16333/j.1001-6880.2018.8.011

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Chemical Constituents from Leaves of Crinum asiaticum var. sinicum and Their Anti-inflammatory Activities

WANG Xin1,2,FAN Qing-fei1,ZHOU Lan1,2,MAO Peng-wei3,ZHANG Yu-mei1,SONG Qi-shi1*   

  1. 1Key Laboratory of Tropical Plant Resources and Sustainable Use,Xishuangbanna Tropical Botanical Garden,Chinese Academy of Sciences,Kunming 650223; 2University of Chinese Academy of Sciences,Beijing 100049,China; 3Puer University,Puer 665000,China
  • Online:2018-09-04 Published:2018-09-04

Abstract: This paper reported the chemical constituents and anti-inflammatory activities of leaves of Crinum asiaticum var. sinicum,an herb for treatment of rheumatoid arthritis in Xishuangbanna Dai medicine.Thirteen compounds were isolated and purified from C. asiaticum var. sinicum by using column chromatography and identified by chemical and spectral analyses.Their structures were elucidated as 7,4′-dihydroxyflavan (1),7,4′-dihydroxy-8-methyl-flavan (2),farrerol (3),stigmast-4-ene-3β,6β-diol (4),byzantionoside B (5),daucosterol+stigmasterol-3-O-glucopyranoside (6),(6R,9R)-3-oxo-α-ionol-9-O-β-D-glucopyranoside (7),5-hydroxy-6,7-methylenedioxy-2-methylchromone (8),n-butyl-β-D-fructopyranoside (9),stigmasterol (10),stigmasterol-3-O-β-D-fructopyranoside (11),β-sitosterol (12),daucosterol (13),among which compounds 2-8 were obtained from this plant for the first time.Extracts from leaves of C. asiaticum var. sinicum showed significant NO inhibitory activities,i.e.anti-inflammatory activities,as well as compounds 7,4′-dihydroxy-8-methyl-flavan (2),farrerol (3),which enriched the study of  C. asiaticum var. sinicum and will be conducive to the exploiting of its medicinal value.

Key words: Crinum asiaticum var. sinicum, chemical constituents, structural identification, anti-inflammatory activities

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