Abstract: Objective:The sinomenine-phospholipids complex was prepared by solvent evaporation method and then analyzed by X-ray diffraction (XRD) and nuclear magnetic resonance (NMR).The rat skin permeation test in vitro was performed by modified Franz diffusion pool.XRD indicated that sinomenine existed in an amorphous form in the complex.From the results of NMR,It was speculated that hydrogen bonds or intermolecular forces existed between sinomenine and phosphatidylcholine.Transdermal permeation experiments showed that phospholipids complex produced higher diffusion ratio,enhancemant rat and cumulative amount in 12 h compared to sinomenine.Therefore,the ability of permeation could be enhanced after sinomenine was formed into phospholipids complex.

Key words: sinomenine, phospholipids complex, orthogonal test, transdermal delivery