Studies on Chemical Constituents of Triterpenoids from Ganoderma sinense

doi:10.16333/j.1001-6880.2018.10.002

Abstract

Abstract: Seven compounds were isolated from the 95% ethanol extract of Ganoderma sinense.Their structures were characterized as Ganosinensic acid C (1),Lucidenic acid A (2),Lucidone B (3),Ganoderenic acid B (4),Ganoderenic acid E (5),Ganoderic acid H (6) and Ganoderic acid I (7).Compound 1 was a new natural product by means of 2D-NMR and HR-ESI-MS experiments.MTT assays were performed to detect the viability of DU145、CEM and Hela cells by different concentrations of 1 Compound 1 showed cytotoxic activities with IC₅₀ values of 28.8±1.5 μMol/L against Hela cells.

Key words: Ganoderma lucidum, ganoderma sinense, ganosinensic acid C, triterpenoids, chemical constituents, cytotoxicity

CLC Number:

R93
Q946

DU Lin1,LIU Yu-rong1,YE Jun1,FU Xiao-hong1,DU Wei2*. Studies on Chemical Constituents of Triterpenoids from Ganoderma sinense[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2018, 30(10): 1669-1673.

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Studies on Chemical Constituents of Triterpenoids from Ganoderma sinense

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