Abstract: Sixteen compounds were isolated from the stems of Cycas revoluta by various column chromatography involving silica gel,Al₂O₃,and Sephadex LH-20.Their structures were identified as 5,6-dehydrosugiol (1),cunningine A (2),6-hydroxy-5,6-dehydrosugiol (3),6α-hydroxy-7-oxoferruginol (4),ligballinol (5),xanthoxyol (6),callislignan A (7),(2R,3R)-bis［(4-hydroxy-3-methoxyphenyl)methyl］-1,4-diacetate (8),secoisolariciresinol (9),dihydrokaempferol (10),4′-methylluteolin (11),5-methoxypinosylvin (12),N-benzoylphenyl alaninol (13),(E,4R)-4-hydroxy-4,5,5-trimethyl-3-(3-oxobut-1-enyl)cyclohex-2-enone (14),3-hydroxy-5α,6α-epoxy-β-ionone (15),and acuminantin (16) based on HR-ESI-MS,¹H,and ¹³C NMR spectroscopic data.All the isolates were obtained from this genus for the first time,of which compounds 13 and 16 were firstly reported as the natural products.This is the first time to reveal abietane-type diterpenes (1-4) and stilbene (12) in this genus.Compound 11 showed moderate α-glucosidase inhibitory activity in vitro,with an inhibition rate of 52.51±2.63 % at the concentration of 198.00 μg/mL.

Key words: Cycas revoluta, chemical constituents, abietane-type diterpenes, stilbenes, α-glucosidase