NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2019, Vol. 31 ›› Issue (2): 264-268. doi: 10.16333/j.1001-6880.2019.2.013

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Chemical constituents of Bridelia retusa and their anti-neuroinflammatory activity

FENG Kai1,HUA Pei2,GU Qiong2,HE Lin3,TENG Xi-feng1*,ZENG Ling-jie1*   

  1. 1School of Chinese Medicine,Guangdong Pharmaceutical University,State Administration of Traditional Chinese Medicine Key Laboratory for Production and Development of lingnan Medicinal Materials; 2School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhuou 510006,China; 3School of Chemistry and Chemical Engineering,Guangdong Pharmaceutical University,Guangdong Provincial Cosmetics Engineering and Technology Research Center,Zhongshan 528458,China
  • Online:2019-03-07 Published:2019-03-07

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Abstract: To investigate the chemical constituents and anti-neuroinflammatory activity from the bark of Bridelia retusa,we isolated and identified eleven compounds from the bark of B.retusa through various column chromatography.Based on the NMR and MS spectra,their structures were identified as gallic acid (1),friedelin (2),ferulic acid heptacosyl ester (3),sinapaldehyde (4),syringaldehyde (5),syringaresinol (6),psoralen (7),bakuchiol (8),pentacosanoic acid (9),telfairic acid (10),1-Linoleoylglycerol (11).Compounds 3-11 were firstly isolated from the genus Bridelia.All the isolated compounds 1-11 were evaluated for their inhibition of NO production in LPS-induced BV-2 cells.Among of them,compounds 4,5,10 and 11 exhibited potent inhibition with IC50 values of 12.57,8.41,5.86 and 5.86 μM,respectively.

Key words: Bridelia retusa, friedelin, phenols, organic acid, anti-inflammatory

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