Abstract: To study the effects of different components of Radix Aconiti Lateralison rats with acute heart failure (AHF) in hemodynamics and neurohumoral factors.Use propafenone hydrochloride to copy the model rats of AHF.Then,observe and record the change of HR,+dp/dt_max and-dp/dt_max after administration 5,10,20,30,60 min,and measure the concentration of Ang-Ⅰ,Ang-II,TNF-α,ANP by blood sampling after 60 min by ELISA.After modeling with propafenone hydrochloride,HR,+dp/dt_max were significantly decreased and-dp/dt_max was significantly increased,and Ang-Ⅰ,Ang-II,TNF-α,ANP were trend to rise.Compared with the model group,total alkaloids and water-soluble alkaloids can increase the HR,+dp/dt_max and decrease the-dp/dt_max in varying degrees at all points of time;total alkaloids,water-soluble alkaloids,fat-soluble alkaloids and polysaccharides had the tendency to reduce the concentration of Ang-Ⅰ,Ang-II,TNF-α,ANP,which were increased by modeling.In conclusion,the total alkaloids had the most significant effect of improving hemodynamics,followed by the water-soluble alkaloids,both of which could affect the neurohumoral factors associated with heart failure.Thus,it can be seen that the water-soluble alkaloids and total alkaloids are the main material basis in playing the role of cardiac.

Key words: Radix Aconiti Lateralis, different components, acute heart failure