Abstract: Eight compounds were isolated from the rice fermentation of a psychrophilic fungus Pseudogymnoascus pannorum.Their structures were identified as L-pyroglutamyl-L-phenylalanine (1),(R)-N-acetylphenylalanine (2),(R)-N-acetyltryptophan (3),methyl 2-hydroxy-4-(3-hydroxy-5-methylphenoxy)-6-methylbenzoate (4),2-hydroxy-4-(2-hydroxy-3-methoxy-5-methylphenoxyl)-6-methylbenzoate (5),vanillic acid (6),1,3,5-trimethoxybenzene (7),and linoleic acid (8).Among them,compounds 1 and 2 were first isolated from natural resources,while others were isolated from the genus of Pseudogymnoascus for the first time.Compounds 1-8 did not show cytotoxicity against human hepatoma HepG-2 or human breast cancer MCF-7 cells.

Key words: psychrophilic fungus, genus Pseudogymnoascus, Pseudogymnoascus pannorum, secondary metabolites