Abstract: Resveratrol,one of naturally occurring stilbenoids,has various biological activities while nitric oxide,a gaseous molecular messenger,can inhibit tumor growth and reverse multidrug resistance of cancer cell at high concentration.As an important class of NO donors,Furoxans are thermally stable compounds.The present investigation synthesized conjugate of resveratrol and furoxans,and tested anti-tumor activity of these compounds by MTT assay.The results showed anti-tumor activity of conjugate of resveratrol and furoxans was more potent than those of resveratrol,furoxans or mixture of resveratrol and furoxans.It is evident that conjugate of resveratrol and furoxans has significant synergistic effects.

Key words: resveratrol, furoxans, NO donor, anti-tumor activity