Antibacterial activity of TTS-12 against T.mentagrophytes in vitro and in vivo

doi:10.16333/j.1001-6880.2019.4.023

Abstract

Abstract: In the study,we evaluated the antibacterial activity of TTS-12 against T.mentagrophytes in vitro and in vivo.The M38-A2 method of CLSI was used to detect the minimum inhibitory and fugicide concentration.When guinea pigs were affected,their skin culturing and pathologic changes in local lesions of guinea pig model before and after treatment were record.The effects of low dose,medium dose and high dose of TTS-12 gels on symptom scores were observed.In the treatment period,all treatment group showed a more significant leision score decrease(P＜0.01),high dose and medium-dose group increased negative rate on fungal reculture(P＜0.05),TTS-12 showed high antibacterial activities against T.mentagrophytes and also had a certain therapeutically effect on guinea pig that infected with Trichophyton mentagrophytes.

Key words: TTS-12, T.mentagrophytes, antibacterial activity, guinea pig, tinea corporis model

CLC Number:

R285.5

CHEN Yan-jie1,2,3,LIU Chuan-yi2,3,LYU Man-xia1,2,FANG Qiong-tong2,3,WU Xin-rong1,2,3*. Antibacterial activity of TTS-12 against T.mentagrophytes in vitro and in vivo[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2019, 31(4): 704-710.

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Antibacterial activity of TTS-12 against T.mentagrophytes in vitro and in vivo

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