Abstract: To solve the problem of anthocyanin stability in Lycium Ruthenicum Murr,the Box-Behnken design was used to optimize the formulation of Lycium Ruthenicum Murr extract effervescent tablet and evaluate its quality.Using acid-base mixed granulation tableting method,single factor experiment was used to select the individual excipients of the tablets:disintegrating agents,filler,lubricant and sweetener.The response surface test was used to optimize the prescription with sensory evaluation to determine the optimal formulation.The optimum formula was 32% citric acid,25% Lycium Ruthenicum Murr extract,24% sodium bicarbonate,16% lactose,3% sodium cyclamate and 1% PEG 6000.The quality of the optimal formula was evaluated and the indicators met the requirements,the anthocyanin content was 8.06 mg/g.The effervescent tablet has a smooth surface,good effervescence effect,and a Lycium Ruthenicum Murr aroma,which provides a theoretical basis for actual production.

Key words: Lycium Ruthenicum Murr extract effervescent tablets, single-factor experiment, response surface test, quality evaluation