Abstract: To synthesize the N-derivation of azasugars isolated from Suregada glomerulata.To analyze the N-substituent group affect the inhibit activity of α-glucosidase.N-methyl,N,N-dimethyl,N-butyl and N-oxidate derivatives were synthesized,and the bioactivity was tested in vitro aganist α-glucosidase.Seven compounds were synthesized,and the structure was confirmed by ¹H NMR,¹³C NMR and MS.The preliminary pharmacological test results showed that all derivatives did not enhance the inhibitory activity.Compound 5,a N,N-derivative,possessed inhibitory activity against α-glucosidase,which is worthy for further study.

Key words: azasugar, Suregada glomerulata, &alpha, -glucosidase, inhibitory activity