Abstract: This study extracted seabuckthorn flavone from seabuckthorn fruit residue and studied the regulation and mechanism on hyperlipidemia rats.The hyperlipemia rats were administrated with high fat diet,then the pathological changes of hepatic tissue after administration of seabuckthorn flavone for 30 days were observed,the content of four blood lipids and 17 small molecules in urine were measured.The regulation of TC with seabuckthorn flavonoids in hyperlipidemia rats is most obvious,TG,HDL,LDL had improved slightly,but TG,HDL,LDL had no significant difference statistically.The HE staining of liver tissue shows the oil accumulation in liver of hyperlipidemia rats with different dosage of seabuckthorn flavone was ameliorated significantly the 17 kinds of amino acid regulation.The seabuckthorn flavonoids can regulate the blood lipid of.hyperlipemia.and the tryptophan,phenylalanine,serine,leucine,arginine and other amino acids in the urine can also be regulated by changing the physical function.

Key words: seabuckthorn, flavone, hyperlipidemia, liver injury, pharmacodynamics