NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2019, Vol. 31 ›› Issue (增刊1): 131-135. doi: 10.16333/j.1001-6880.2019.S.023

• Article • Previous Articles     Next Articles

Study on the release and immunostimulatory activity of 5-FU-loaded Astragalus polysaccharide/PLA microspheres

XIA Yun-ya,BAO Hui,XU Da-da,ZHANG Wei-jie*   

  1. School of Life science and engineering,Lanzhou University of Technology,Lanzhou 730050,China
  • Online:2019-08-06 Published:2019-08-06

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Abstract: The purpose of this study was to develop the feasibility of using Astragalus polysaccharides to increase the drug-loading capacity of microspheres.APS/5-FU loaded polylactic acid (PLA) microspheres were prepared by solvent evaporation.The structure of the composite microspheres was determined by scanning electron microscopy (SEM) and FT-IR,and the drug-loading properties of the prepared microspheres (adding APS / 5-FU / PLA,no APS / 5-FU / PLA) were investigated.The results showed that PLA microspheres had higher drug loading,encapsulation efficiency and immunostimulatory activity after the addition of APS.The AFU-loaded 5-FU/PLA microspheres show great potential as a drug carrier for sustained release.

Key words: APS, microspheres, immunostimulatory activity, drug release

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