NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2019, Vol. 31 ›› Issue (10): 1753-1757. doi: 10.16333/j.1001-6880.2019.10.012

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Indole alkaloids from Bousigonia mekongensis

WANG Ya-lan1,2,4,ZHANG Jin-ping1,2,4,WANG Zhi-wei3*,WANG Xiao-jing1,2,4*   

  1. 1School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,China;2Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan 250062,China;3Shandong Analysis and Test Center,Qilu University of Technology (Shandong Academy of Sciences),Jinan 250014,China;4Key Laboratory for Biotech-Drugs Ministry of Health,Key Laboratory for Rare-Uncommon Diseases of Shandong Province,Jinan 250062,China
  • Online:2019-10-28 Published:2019-11-11

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Abstract: In order to investigate the chemical constituents and biological activities of Bousigonia mekongensis,nine compounds were isolated from the roots of B. mekongensis by repeated column chromatography over silica gel,RP-18 and preparative-HPLC.On the basis of NMR and MS spectroscopic analysis,their structures were identified as quebrachamine (1),(-)-isoeburnamine (2),rhazinilam (3),tetrahydroalstonine (4),leuconodine D (5),leucophyllidine (6),(-)-O-ethyleburnamine (7),(-)-ebumamenine (8),eburenine (9),respectively.Compound 1 and 3-7 were obtained from this genus for the first time,and compound 2 was isolated from this plant for the first time.All compounds were evaluated the activities of preventing high glucose-induced podocyte injury and inhibiting of amyloid-β.Compound 6 exhibited moderate Aβ inhibitory activity (IC50= 26.1 μM),other compounds showed no activity.

Key words: Bousigonia mekongensis, indole alkaloids, bioactivity, chemical constituents

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