NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2020, Vol. 32 ›› Issue (1): 75-80. doi: 10.16333/j.1001-6880.2020.1.011

• Article • Previous Articles     Next Articles

Study on the secondary metabolites and their bioactivities of the endophytic fungus Colletotrichum sp. HK-08 from the leaves of Nerium indicum

ZHENG Hao1,2,MEI Wen-li2,CAI Cai-hong2，GAI Cui-juan2,DAI Hao-fu2,TAN Zhi-qiong1 *,CHEN Hui-qin2 *   

  1. 1School of Life and Pharmaceutical Sciences,Hainan University,Haikou 570228,China; 2Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China
  • Online:2020-01-28 Published:2020-03-25

PDF (PC)

312

Abstract: Eleven compounds were isolated and purified from the endophytic fungus Colletotrichum sp. HK-08 from the leaves of Nerium indicum by various chromatographic techniques,and the structures were identified as butyl 2-(4-hydroxyphenyl)acetate (1),4-hydroxyphenethyl acetate (2),phenethyl 2-phenylacetate (3),phenethyl 2-(4-hydroxyphenyl)acetate (4),4-hydroxyphenethyl 2-(2-hydroxyphenyl)acetate (5),4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (6),4-hydroxybenzaldehyde (7),2-(2-hydroxyethyl)phenol (8),4-hydroxybenzoic acid (9),1-(4-hydroxyphenyl)ethenone (10) and 3a-hydroxyindoline (11).Among them,compounds 4,5 and 11 were new natural products,and 1~6 and 11 were isolated from Colletotrichum sp. for the first time.The bioactivity results showed that compounds 4 and 6 exhibited certain cytotoxic activities.

Key words: Nerium indicum Mill., endophytic fungus, Colletotrichum sp., secondary metabolite, cytotoxic activity

CLC Number: