Abstract: The secondary metabolites of A. fumigatus sp.,a fungus isolated from the jellyfish Nemopilema nomurai collected off the southern coast of Korea,were studied.Seven compounds were obtained from the rice static fermentation products,which were purified by the methods of silica gel,Sephadex LH-20 gel,reversed-phase and semi-preparative HPLC column chromatography.The structures of these compounds were identified as sinulariapeptide C(1),simplicilliumtide A(2),simplicilliumtide B(3),sinulariapeptide D(4),4-hydroxy-17R-methylincisterol(5),methyl 3-hydroxyphenyl acetate(6) and dibutyl phthalate(7) by physical and chemical properties,spectroscopic analysis,and comparison with the reported literatures.Compounds 1-7 were isolated from the jellyfish-derived fungus A. fumigatus for the first time.

Key words: Nemopilema nomurai, jellyfish-derived fungus, Aspergillus fumigatus, secondary metabolites