Abstract: Actinomycetes are an important microbial resource.Actinomycetes and their bioactive substances have become the focus of drug research and development.Based on the papers we researched since 2015,we reviews the species,origin,classification of bioactive substances,chemical structure and antitumor effects of marine actinomycetes producing antitumor bioactive substances.In this paper,42 species of Streptomyces and other rare actinomycetes are involved.76 different kinds of bioactive compounds are reported which have various antitumor effects.This paper points out the problems in the research and development of antitumor bioactive substances derived from actinomycetes,and proposes solutions to the problems.

Key words: marine, actinomycetes, bioactive substances, anti-tumor