Isoquercitrin has good research and development value.The distribution of isoquercitrin was introduced,and the current preparation methods,the physical and chemical properties,pharmacological activities and safety of isoquercitrin were summarized in this paper.The study of single component α-L-rhamnosidase with high efficiency and specificity are the effective way to prepare isoquercitrin from rutin.From the perspective of research status and development trend,isoquercitrin can be used for food or drug addition within a certain dose range.On the basis of further in-depth study of pharmacology and safe dose,isoquercitrin is expected to play a greater role in the development of health products.