To explore the mechanism of Schisandra sphenanthera in treating hepatic injury by network pharmacology and molecular docking.The active ingredients of S. sphenanthera and related targets for treating hepatic injury were screened from imultiple databases.Cytoscape3.2.1 software was used to construct a network diagram of active ingredients-potential targets.The protein interactions network was constructed using the String database.The GO and KEGG pathways involved in the targets were analyzed by R.Then they were verified by molecular docking.At last,31 active chemical components of S. sphenanthera and 358 targets related to hepatic injury were screened.The KEGG analysis mainly focused on 168 related signal pathways,the results showed that S. sphenanthera may play a role through PIK3CA,MAPK1,MAPK3,STAT3 and other key targets,these targets were mainly Neuroactive ligand-receptor interaction,Proteoglycans in cancer,Prostate cancer,EGFR tyrosine kinase inhibitor resistance,Hepatitis B,ErbB signaling pathway and other pathways;The molecular docking results also show good binding interaction.This study revealed the mechanism of S. sphenanthera to treat hepatic injury through multi-component act on multi-targets and multi-pathway synthesis,and provided a theoretical basis for biological experiments.