To explore the rule of application of traditional Chinese medicine in the treatment of epilepsy,and to explore the potential targets of the chemical constituents in the Chenpi and Banxia through the use of network pharmacology techniques to explore the potential components,multi-target and multi-channel mechanism of action of epilepsy.China’s full-text journal database (CNKI),VTTMS,VANFUN are used to collect Chinese herbal compound for treating epilepsy,and Apriori algorithm is used to establish a correlation model,so as to explore the drug compatibility rules hidden in the database and analyze drugs using TCMSP,OMIM,STRING and DAVID databases to analyze the interactions and related pathways between disease targets.Among the 131 papers that met the criteria,221 Chinese medicines were used in 226 prescriptions,of which Chenpi-Banxia was the highest confidence drug,a total of 268 targets were retrieved from 18 target compounds,a total of 886 target genes related to epilepsy were obtained and 41 targets were obtained by matching the relevant targets of the effective component of the Chenpi and Banxia.The common targets obtained by Cytoscape acquired the genes of AKT1,MAPK3,FOS and other genes in the PPI network.It is of great significance in the treatment of epilepsy in the Chenpi-Banxia.GO and KEGG enrichment analysis of key target genes can obtain the combination of Chenpi-Banxia was mainly involved in the response of cells to oxidative stress,the reaction to reactive oxygen species,the reaction of cells to cadmium ions,and other biological processes and regulated Serotonergic synapse,Kaposi sarcoma-associated herpesvirus infection,Hepatitis B and other pathways in the treatment of epilepsy.The mechanism of Chenpi-Banxia combination in the treatment of epilepsy was analyzed,which provided a new method and new idea for the treatment of epilepsy with traditional Chinese medicine.