To explore the mechanism of the prevention and treatment of Lianpuyin on the pathological of "inflammatory-cancer transformation" of chronic atrophic gastritis,we searched and got the active ingredients,targets and molecular of all traditional Chinese medicines in Lianpuyin from the TCMSP database,and set up a data set;Then,the disease targets of chronic atrophic gastritis were screened in the GeneCard and OMIM databases,and they were intersected with the target of Lianpuyin's traditional Chinese medicine ingredients;Using Cytoscape 3.6.2 software to build the "Chinese medicine component-target-disease" network and PPI network,and got the core ingredients and core targets through cluster analysis;Use R (clusterProfiler package) software to perform GO and KEGG enrichment analysis on common targets;and use AutodockTool and Vina software to perform molecular docking proof on core targets and core ingredients.The study found that Lianpuyin's traditional Chinese medicine contains 45 chemical active ingredients,193 targets,686 disease targets,and 81 drug-disease targets;Through PPI network and "component-target-disease" network analysis,FOS,ICAM1,IL1B,IL6,IL10,CCL2,CXCL2,RELA,MAPK8,MAPK1,IFNG,CXCL8 were found as core targets,and kaempferol,baicalein,β-sitosterol,glycitein,stigmasterol,quercetin are the main active ingredients of Chinese medicine contained in Lianpuyin;Through the enrichment analysis of GO and KEGG,it was found that Lianpuyin may mainly control chronic atrophy by regulating biological processes such as cytokine receptor binding,cytokine activity,ubiquitin-like protein ligase binding,receptor ligand activity,and kinase regulating activity.Gastritis plays a therapeutic role.The mechanism may mainly involve IL-17 signaling pathway,Toll-like receptor signaling pathway,C-type lectin receptor signaling pathway,Th17 cell differentiation signaling pathway,etc.;Finally,through molecular docking experiments,it was found that the main active ingredients contained in Lianpuyin traditional Chinese medicine have strong binding to the core target of chronic atrophic gastritis.Studies have shown that multiple active ingredients contained in Lianpuyin can act on multiple signaling pathways through various biological processes,and thus play a preventive and therapeutic role in the pathological process of "inflammatory-cancer transformation" of chronic atrophic gastritis.