The effect of oral Emilia prenanthoides DC.(EP) in rats with chronic pelvic inflammatory disease was explored.Serum levels of inflammatory factors (TNF-α,IL-2,IL-6),uterine swelling and tissue lesions were used as evaluation indicators.Phenol gel was used to prepare chronic pelvic inflammatory disease rats which were divided into blank group,model group,sham operation group,gynecological qianjin tablet positive group (0.86 g/(kg·d)),and EP high,EP medium and EP low dose groups (0.8,1.6 and 3.2 g/(kg·d)).The contents of TNF-α, IL-2,IL-6 in the serum and the degree of swelling of the uterus were used to investigate the inflammation in the rats.The morphological evaluation of the rats was performed based on the pathological changes of the uterus influences.This was found to occur after oral administration of EP in rats,where the inflammatory cytokine TNF-α, IL-2, IL-6 was inhibited(P<0.05),the inflammatory lesions of uterus were improved,the infiltration of inflammatory substances in cells was reduced.In conclusion,the EP can effectively inhibit the related inflammatory response in rats and have a significant therapeutic effect on chronic pelvic inflammation.The mechanism may be related to the reduction of TNF-α, IL-2 and IL-6 content.