To investigate the effect of epigallocatechin gallate (EGCG) combined with cisplatin on cell proliferation of human osteosarcoma MG-63 cells and its possible mechanism.MG-63 cells were treated with different concentrations of EGCG and cisplatin alone or in combination.The cell growth inhibition rate was measured by CCK-8 morphology was observed by microscope,the Transwell chamber detects the number of cell invasions,and the scratch test detects the cell migration ability;Western blot detection of Bax,Bcl-2,Bcl-xL,MMP-2,MMP-9,Caspase-3 and cleaved Caspase-3.The results showed that the ability of proliferation,invasion and migration of MG-63 cells decreased with the increase of the dose of EGCG and cisplatin (P<0.05),and the combined drug inhibition was stronger;the expression levels of Bcl-2,Bcl-xL,MMP-2 and MMP-9 were significantly down-regulated (P<0.05),and the levels of Bax,Caspase-3 and cleaved Caspase-3 were significantly up-regulated(P<0.05);Compared with the gallic acid catechin gallate group and the monotherapy application of the platinum group,the MG-63 cells in the combination group had the highest inhibition rate,and the related protein expression was also more significant.To sum up,EGCG can effectively inhibit the proliferation of human osteosarcoma MG-63 cells and induce apoptosis.The effect is more obvious when combined with cisplatin.