Hibiscus tiliaceus (Hibiscus sp.,Malvaceae),the semi-mangrove plant,located in the tropics.It possesses the effects in clearing heat and relieving cough,detoxifying and swelling.The same or similar structures as the host plants can be produced from H. tiliaceus endophytes,and its metabolites have novel active molecules.Currently,a variety of endophytic species have been isolated and identified,which included Eurotium rubrum, Penicillium commune, Penicillium oxalicum, Fusarium sp..Pharmacological activities of metabolites from H. tiliaceus endophytes were summarized,and alkaloids,nucleoside compounds,anthraquinones,polysubstituted benzene compounds,triterpenoids,etc.have been obtained.Modern pharmacological studies show that the metabolites of H. tiliaceus endophytes have antibacterial,anti-tumor,anti-inflammation and other pharmacological activities.This paper reviews the research status of H. tiliaceus endophytes and its metabolic products and pharmacological activity in recent 20 years.This review also aims to provide scientific basis and reference for the development and application of the medicinal value of the semi-mangrove plant H. tiliaceus.