To improve the poor solubility and stability,Chuanxiong Rhizoma volatile oil-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex was prepared.It was prepared by single-phase method,taking the inclusion rate as evaluation index,and the inclusion process conditions were optimized by orthogonal test.The inclusion complex was characterized by SEM and IR,as well as,the solubility and stability were evaluated.The optimal process conditions for single-phase method to prepare the inclusion complex were as follows: Ethanol concentration: 95%,volatile oil∶HP-β-CD(W/W)=1∶10,HP-β-CD∶ethanol(W/V)=1∶3,the inclusion rate reached 92.34%.The characterization results showed that the inclusion complex had been formed,HP-β-CD significantly improved the solubility of Chuanxiong Rhizoma volatile oil,in addition,the inclusion complex had good stability at 60 ℃ for 10 days.The optimized inclusion process of HP-β-CD inclusion complex of Chuanxiong Rhizoma volatile oil is simple and efficient with good reproducibility and high inclusion rate,which could significantly improve the solubility and stability of Chuanxiong Rhizoma volatile oil.