To study the chemical constituents and biological activities of Piper kadsura.The chemical constituents of the stems of Piper kadsura were purified by silica gel column chromatography,Sephadex LH-20 and preparative liquid chromatography.Based on various spectroscopic methods,13 amide alkaloids were identified as(2E,4E)-N-isobutyl-6-oxodeca-2,4-dienamide（1）,(4,5)-trans-N-isobutyl-4,5-epoxy-2E-decadienamide（2）,N-isobutyl-4-hexanoyl-4-hydroxypyrrolidin-1-one（3）,sylvamide（4）,N-isobutyl-2E,4E-octadienamid（5）,pellitorine（6）,N-isobuty-2E,4E-dodecadienamide（7）,N-isobutyl-2E,4E-octadecadienamide（8）,N-2′-methylbutyl-2E,4E-decadienamide（9）,N-isobutyl-2E,4E,12Z-octadecatrienamide（10）,N-isobutyl-2E-decenamide（11）,dihydropiperlonguminimine (12) and futoamine (13).Compound 1 was a new compound,compound 2 was a new natural product,and compounds 3-7,9 and 10 were isolated from this plant for the first time.The neuroprotective activity of compounds 1-10 were tested in vitro by using MPP⁺ injured PC12 cell,compound 6 displayed a significant protective effect on MPP⁺ induced PC12 cell injury at 20 μM (P < 0.01).