Based on data mining,network pharmacology and molecular docking,the molecular mechanism of frankincense-myrrh in the treatment of breast cancer was discussed.The frankincense-myrrh pair is mined by Apriori association rule algorithm and the decision tree model is established.The “compound-target” visual network and protein interaction network were constructed by using Cytoscape software.Then,go enrichment analysis and KEGG pathway enrichment analysis were carried out by using David database,and the active components with high degree value obtained from “active component-target” topology analysis were connected.The results showed that there were 53 active components of frankincense-myrrh,329 related targets and 81 core target information were obtained by topological analysis.Go analysis included 248 biological processes,60 cell components,94 molecular functions,and 39 KEGG enrichment results.Molecular docking results showed that the components with good docking with key targets were 3-methoxyfuraguanosine-9-en-8-one,mastic acid and quercetin.This study preliminarily reveals that frankincense-myrrh plays a role in the treatment of breast cancer through multi-component,multi-target and multi-channel,and provides a new direction and basis for drug research and development.