NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2022, Vol. 34 ›› Issue (1): 57-62. doi: 10.16333/j.1001-6880.2022.1.008

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Study on chemical constituents and their anti-inflammatory activity from stems of Strophanthus divaricatus

YU Miao1,2,RAN Hong-ling1,2,MEI Wen-li1,2,HUANG Sheng-zhuo1,2,WEI Yan-mei1,CAI Cai-hong1,2,DAI Hao-fu1,2,WANG Hao1,2*   

  1. 1Key Laboratory of Natural Products Research and Development from Li Folk Medicine of Hainan Province,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences;2Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province,Hainan Academy of Tropical Agricultural Resources,Haikou 571101,China

  • Online:2022-01-28 Published:2022-01-28

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Abstract: To study the chemical constituents and their anti-inflammatory activity from the stems of Strophanthus divaricatus,thirteen compounds were isolated from its ethyl acetate fraction of ethanol extract by using chromatographic techniques including silica gel,Sephadex LH-20 etc.Their structures were elucidated on the basis of spectroscopic data analysis as hederagenin (1),(-)-loliolide (2),(3S,5R,6S,7E)-3,5,6-trihydroxy-7-megastigmen-9-one（3）,(3R,6R,7E)-3-hydroxy-4,7-megastigmadien-9-one（4）,(+)-pinoresinol (5),epipinoresinol (6),4,4′-dihydroxy-3,3′-dimethoxybenzophenone (7),6-hydroxynaringenin (8),scosolrtin (9),6,7-dimethylesculetin (10),indazole (11),vanillic acid (12),and p-hydroxybenzoic acid (13).Compounds 1~4 and 6~13 were identified from this plant for the first time.Compound 5 showed a significant inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells with IC50 value of 18.09 ± 1.09 μM.

Key words: Strophanthus divaricatus, chemical constituent, anti-inflammatory activity

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