Study on chemical constituents and antibacterial activity of Carpesium faberi

doi:10.16333/j.1001-6880.2022.4.007

Abstract

Abstract:

In order to study the chemical composition and antibacterial activity of Carpesium faberi, 14 compounds were obtained from the ethanol extract of C. faberi by applying various chromatographic techniques.Their structures were elucidated and identified as granilin (1),4α,10α-dihydroxy-1βH,5βH-guai-11(13)-en-12,8α-olide (2),4β,10β-dihydroxy-5α(H)-1,11(13)-guaidien-8α,12-olide (3),4-epi-isoinuviscolide (4),11(13)-dehydroivaxillin (5),carabrone (6),vomifoliol (7),cassipourol (8),4′,5′-dehydrodiodictyonema A (9),(3R)-8-Hydroxylinalool (10),cholest-7-en-3β-ol (11),stigmasterol (12),5,8-epidioxy-5α,8α-ergosta-6,22E-dien-3β-ol (13),stigmasta-5,22-diene-3β,7α-diol (14).Among them,compounds 2 and 7-14 were obtained from this plant for the first time.The antibacterial activity of compounds 1-14 was preliminarily evaluated,and compound 1 showed weak activity against Bacillus subtilis;compounds 6 and 10 showed weak activity against Candida albicans.

Key words: Carpesium faberi, chemical constituents, isolation and identification, antibacterial activity

CLC Number:

R284.1
R932

CHEN Jie, WANG Dan, ZHANG Xiong, PENG Ming-you, XU Ran, YAN Ying, WANG Ying. Study on chemical constituents and antibacterial activity of Carpesium faberi[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(4): 598-605.

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Study on chemical constituents and antibacterial activity of Carpesium faberi

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