The mangrove endophytic fungus Aspergillus fumigatus SAS10 from Sonneratia apetala was fermented by using rice medium,and eight compounds were obtained by isolation and purification of metabolites with modern separation techniques such as column chromatography on silica gel,column chromatography on Sephadex LH-20,and semi-preparative HPLC.On the basis of mass and NMR spectroscopic data,their structures were identified as asperpyrone A (1),aurasperone B (2),asperpyrone C (3),asperpyrone D (4),dianhydro-aurasperone C (5),aurasperone A (6),fonsecinone A (7) and rubrofusarin B (8),respectively.All of compounds were reported from the mangrove endophytic fungus Aspergillus fumigatus for the first time,and Aspergillus fumigatus SAS10 is capable of producing a large number of dimeric naphthopyrones metabolites.The antimicrobial activities showed that all compounds exhibited different degrees of inhibitory activities against Staphylococcus aureus,Escherichia coli and Methicillin-resistant Staphylococcus aureus.