Chaetomium globosum is a fungal species of Ascomycota,belonging to Ascomycota, Pyrenomycetes, Sordariomycetidae, Sordariales and Chaetomium.It is widely distributed in air and soil,and it is also one of the most common endophytic fungi in plants,which can produce a wide variety of secondary metabolites.These seconday metabolites have a variety of biological activities such as antifungal and nematocidal activities to be prepared into biocides,which have a good biological control potential against plant pathogenic fungi and root knot nematode (Meloidogyne spp.).In this paper,the biocontrol mechanism of C. globosum against plant pathogenic fungi and root knot nematodes was reviewed and discussed,in order to provide some references for the comprehensive management of plant pathogenic fungi and root knot nematodes and for the development of new biopesticides.