AIDS,also known as acquired immunodeficiency syndrome,is an infectious disease caused by human immunodeficiency virus.At present,there is no drug that can completely eradicate HIV/AIDS,and no related vaccine has been successfully developed.Plant-derived natural products have become an indispensable part of the prevention and treatment of AIDS or lead compounds due to their rich variety,diverse structures,and lower side effects.This article briefly reviews some plant-derived natural products with anti-HIV activity in recent five years,hopes provides potential lead compounds for the development of anti-HIV drugs by summarizes related research progress.