In recent years,many research groups have carried out a large number of experimental studies based on andrographolide as a lead compound in the development of antitumor,anti-inflammatory,antibacterial and antiviral drugs.In order to provide some guidance for the further research and development of new drugs based on andrographolide,this paper systematically summarizes the research progress in the synthesis and activity of andrographolide derivatives in recent years and reveals their structure-activity relationship.