The secondary metabolites of the rice solid fermentation of marine-derived fungus Aspergillus terreus were studied.Thirteen compounds were isolated and purified by macroporous resins,silica gel column chromatography,and semi-preparation liquid method.Their structures were identified as butyrolactone I (1),3-hydroxy-5-［［4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl］methyl］-4-(4-hy-droxyphenyl)-2(5H)-furanone (2),(±)-asperteretal F (3),asperimide A (4),lovastatin (5),terretonin (6),methyl-3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate (7),bisdethiobis(methylthio)acetylaranotin (8),acetylaranotin (9),cyclo-(L-pro-L-Val) (10),cyclo(D-Leu-D-Pro) (11),callyspongidipeptide A (12),(3R,4R)-6,7-dimethoxy-4-hydroxymellein (13) using NMR and HR-ESI-MS data,and by comparing the information with literature data.Compound 12 was isolated from A. terreus for the first time.The protective effects of these compounds on the viability of hypoxia/reoxygenation-induced PC12 cell damage were evaluated by CCK-8 assay in vitro,the results showed that compounds 1,3,5,6,and 7 could significantly reduce the cell damage caused by oxidative stress,which presented neuroprotective activity in PC12 cells.This study lay a foundation for further exploitation the active secondary metabolites of A. terreus.