Isolation and Identification of Metabolites Produced by Marine Streptomyces sp.S007

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (3): 410-414.

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Isolation and Identification of Metabolites Produced by Marine Streptomyces sp.S007

ZHANG Hong-yu^1,2, QIN Mei³, LI Fu-chao⁴, LAATSCH Hartmut⁵, WANG Hong-peng⁵, QIN Song^1*

¹Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; ²Graduate University of Chinese Academy of Sciences, Beijing 100049, China; ³School of chemistry and chemical engineering, Qufu Normal University, Qufu 273165, China; ⁴Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; ⁵Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen, D-37077, Germany

Received:2010-07-08 Online:2011-06-25 Published:2011-08-08
Supported by:
This work was supported by the International Innovation Partnership Program: Typical Environmental Process and Effects on Resources in Coastal Zone Area, the research fund of Qufu Normal University (XJ0718),the National Natural Science Foundation of China (31000037), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-G-073, KZCX2-YW-216, KZCX2-YW-209)

Abstract

Abstract:

Nine metabolites thymine (1), pyrrole-2-carboxylic acid (2), kalamycin (3), 3-indole propionic acid (4), indol-3-carboxylic acid (5), N-acetyl-tyramine (6), 2'-deoxythymidine (7), N-β-acetyltryptamine (8), and triethylamine hydrochloride (9) were isolated by column and preparative thin layer chromatography from the extract of fermented broth of Streptomycete sp. S007. Their structures were established by NMR and MS data. Among of them, 9 was firstly obtained from Streptomycete; The brine shrimp bioassay showed the mortality rates of kalamycin to brine shrimp are 86. 5% at a concentration of 40 µg/mL, indicating kalamycin possessed significant toxicity on brine shrimp.

CLC Number:

R284.2

ZHANG Hong-yu, QIN Mei, LI Fu-chao, LAATSCH Hartmut, WANG Hong-peng, QIN Song. Isolation and Identification of Metabolites Produced by Marine Streptomyces sp.S007[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(3): 410-414.

References 12

1	Zhao WY(赵文英),Zhu TJ(朱天娇),Gu JY(古静燕),et al.Studies on the chemical constituents and antitumor activity of secondary metabolites of marine-derived Streptomyces sp.3275.Nat Prod Res Dev(天然产物研究与开发),2006,18(3):405-407,417
2	Li FC,Maskey RP,Qin S,et al.Chinikomycin A and B:isolation,structure elucidation and biological activity of novel antibiotics from a marine Streptomyces sp.isolate M045.J Nat Prod,2005,68(3):349-353
3	Maskey RP,Li FC,Qin S,et al.Chandrananimycins A~C:production of novelanti-cancer antibiotics from a marine actinomadura sp.isolate M048 by variation of medium composition and growth conditions.J Antibiot,2003,56(7):622-629.
4	Fotso S,Wu SJ,Qin S,et al.5,7-Dihydroxy-5,6,7,8-tetrahydro-1H-azocin-2-one from a marine-derived Streptomyces sp.Nat Prod Commun,2006,1(1):9-13.
5	Wu SJ,Fotso S,Li FC,et al.N-carboxamido-staurosporine and Selina-4(14),7(11)-diene-8,9-diol,new metabolites from a marine Streptomyces sp.J Antibiot.2006,59(6):331-337.
6	Ding L,Pfoh R，Ruhl S,et al.T-Muurolol sesquiterpenes from the marine Streptomyces sp.M491 and revision of the configuration of previously reported amorphanes.J Nat Prod.2009,72(1):99-101.
7	Solis PN,Wright CW,Andersonetal MM,et al.A microwell cytotoxicity assay using artemia salina (brine shrimp).Planta Med,1993,59(3):250-252.
8	Meyer BN,Ferrigni NR,Putnam JE,et al.Brine shrimp:a convenient general bioassay for active plant constituents.Planta Med,1982,45(5):31-34.
9	Laatsch H.AntiBase,2002,A natural products database for rapid structure determination.ChemConcepts.Weinheim,2002,see Intemet:http://wwwuser.gwdg.de/~ucoc/laatsch/antibase.htm
10	Elin RJ,Wolfe SM.Bacterial Endotoxin.In:Luskin AI,Lechevalier HA (eds.).CRC handbook of microbiology 1973,II:Boca Raton,CRC Press,pp 215-237.
11	Stueber D,Grant MD.13C and 15N chemical shift tensors in adenosine,guanosine dihydrate,2'-deoxythymidine,and cytidine.J Am Chem Soc,2002,124(35):10539-10551
12	Böhlendorf B,Bedorf N,Jansen R,et al.Antibiotics from gliding bacteria,LXXIII indole and quinoline derivatives as metabolites of tryptophan in myxobacteria.Eur J Org Chem,1996,1996(1):49-53.

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Isolation and Identification of Metabolites Produced by Marine Streptomyces sp.S007

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