NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (4): 591-595.

• Article •     Next Articles

Aromatic Amide Metabolites from the Marine-derived Streptomyces lusitanus SCSIO 32

REN Xiang-mei1,2, HUANG Hong-bo1, LIU Jing1,2, ZHANG Yun1,2, MA Jun-ying1, WANG Bo1, ZHANG Chang-sheng1, JU Jian-hua1*   

  1. 1The Chinese Academy of Sciences Key Laboratory of Marine Bio-resourses Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Guangzhou 510301, China; 2Graduate University of the Chinese Academy of Sciences, Beijing 100049, China
  • Received:2011-02-28 Online:2011-08-25 Published:2011-09-13

Abstract: Four aromatic amide metabolites, toluene-2,4-dicarbamic acid dimethyl ester (1), toluene-2,4-dicarbamic acid diethyl ester (2), toluene-2,6-dicarbamic acid dimethyl ester (3) and toluene-2,6-dicarbamic acid diethyl ester (4) were isolated from the marine-derived actinomycetes Streptomyces lusitanus SCSIO 32 from the South China Sea with silica gel column chromatography and revered phase semipreparative-HPLC. Their structures were identified by MS, 1H and 13C NMR spectral data analyses. The structure of 1 was confirmed by single crystal X-ray diffraction. Compounds 2 and 4 were obtained from natural sources for the first time. The strain was identified as a member of Streptomyces genus by analysis of its 16S rRNA gene sequence.

Key words: marine actinomycetes, Streptomyces lusitanus, aromatic amide, secondary metabolites

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