Antioxidation and Genetic Toxicity of Artemisia japonica Extract

Abstract

Abstract:

The experiment was conducted to determine the effects of Artemisia japonica Extract (AJE) on antioxidant parameters and genetic toxicity in mice. Based on the model of immunological liver injury in mice established by injection of Bacillus Calmette Guerin (BCG) and lipopolysaccharide (LPS) from tail vein, mice were fed with AJE of various concentrations. The activities of MDA, GSH-Px, and SOD in mice livers were measured and the results of micronucleus and sperm abnormality were examined. The results showed that the content of MDA in livers was decreased while the activities of GSH-Px and SOD was increased by AJE within certain range of dosage. However, the results of micronucleus and sperm abnormality tests were negative. It was proved that AJE possessed of the relatively high anti-oxidant function and no genetic toxicity effect.

Key words: Artemisia japonica Extract, anti-oxidation, micronucleus test, sperm abnormality test, mice

CLC Number:

ZHANG De-Hua, CHENG Peng-Fei, LING Ling. Antioxidation and Genetic Toxicity of Artemisia japonica Extract[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(1): 39-42.

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Antioxidation and Genetic Toxicity of Artemisia japonica Extract

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