Abstract:

The effects of three different degrees of glucose oligosaccharides (LGOS，MGOS，HGOS) on the oxidative stress and inflammatory response were investigated and the mechanisms were also discussed. Mice of each group were treated with the normal saline，FOS，LGOS，MGOS and HGOS respectively，except feeding the ordinary diet every day. After 21 days，the model mice of the oxidative stress and inflammatory response under LPS induced was established. And the reactive oxygen species (ROS) level，total antioxidant capacity (T-AOC)，catalase (CAT)，glutathione peroxidase (GSH-P_x)，malondialdehyde (MDA) in blood and liver，the content of nitric oxide (NO) and nitric oxide synthase (NOS) activity in liver，the content of Interleukin-1 (IL-1)，tumor necrosis factor (TNF-a) in blood plasma were detected after 4 hours and 18 hours. The results showed that LGOS，MGOS，HGOS could reduce the reactive oxygen species (ROS) levels in blood and liver，the content of NO，the activities of T-NOS and iNOS in liver and the contents of IL-1 and TNF-a in blood plasma (P<0.05)，while increase the T-AOC and the activities of CAT and GSH-P_x. Glucose oligosaccharides could protect the body from oxidative damage and slow down the inflammatory response and the regulatory function. In addition，the regulatory function was enhanced with the increase of average degree of polymerization.

Key words: glucose oligosaccharides, LPS, inflammation, oxidative stress, reactive oxygen species, antioxidase