NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (2): 246-249.

• Article • Previous Articles     Next Articles

Effect of Cactus Extracts on the Expression of VEGF and FGF-2 in Rats with Superficial Second-degree Burns

CHEN Shi-xing, WANG Liang, YANG Zhe, YAN Dong, XIN Yi, ZHANG Cui-li*   

  1. Biotechnology Department of Dalian Medical University, Dalian, 116044
  • Received:2010-04-27 Online:2011-04-25 Published:2011-10-14

Abstract:

In order to determine the effects of wild cactus extracts and edible cactus extracts on the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor 2 (FGF-2) at the superficial second-degree burns,the superficial second-degree burned mice were divided into four groups randomly; wild cactus extracts treated group,edible cactus extracts treated group,drag treated group,and burned group (the wound without treatment). Expression of growth factor of VEGF and FGF-2 were measured by western-blotting. Expressions of VEGF and FGF-2 were higher in wild cactus extracts treated group and edible cactus extracts treated group than those in other groups,but they were different in wild cactus extracts treated group and edible cactus extracts treated group. In conclusion,both wild cactus extracts and edible cactus extracts enhanced the expression of VEGF and FGF and promoted wound healing.

Key words: cactus extracts, superficial second-degree burns, VEGF, FGF-2