Site of Analgesic Action and Its Mechanism of Crebanine

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (2): 341-344.

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Site of Analgesic Action and Its Mechanism of Crebanine

LIN Qing^1* , YANG Lian¹, DUAN Xiao-hua¹, LI Xiu-fang^1,2 , MA Yun-shu¹, DAI Rong²

¹Yunnan University of Traditional Chinese Medicine, Kunming 650500, China; ²Shanghai University of Traditional Chinese Medicine, shanghai 201203, China

Received:2009-12-08 Online:2011-04-25 Published:2011-10-14

Abstract

Abstract:

The main aim was to determine the site of analgesic action and the mechanism of crebanine. The pain animal models of mouse toe injection of formaldehyde，hot plate test and writhing test were used. Mouse vas deferentia electrostimulation test was used to study the effect on morphine receptor of crebanine. As a result，the significant analgesic action of crebanine (3.2 mg/kg) was observed in three animal pain models. Moreover，crebanine could strongly inhibit the contraction of vas deferentia induced by electrical stimulation. The effect was not antagonized by naloxone. Crebanine had a central-like analgesic effect，and its mechanism was independent of the morphine-receptor.

Key words: crebanine, analgesic effect, morphine receptor

LIN Qing, YANG Lian, DUAN Xiao-Hua, LI Xiu-Fang, MA Yun-Shu, DAI Rong. Site of Analgesic Action and Its Mechanism of Crebanine[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(2): 341-344.

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Site of Analgesic Action and Its Mechanism of Crebanine

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