Review on Progress of Bovine Lactoferricin and Its Derivatives Peptides

Abstract

Abstract:

Lactoferricins are a class of antibacterial peptides isolated after gastric-pepsin digest of the mammalian iron-chelating-protein lactoferrin. They are the active center of the lactoferrin. Investigation of antibacterial activity found the peptides derived from the bovine had the highest antimicrobial activity. An alanine-scan of the most active 15-residue bovine lactoferricin derivative was performed that tryptophan was important for the antibacterial activity. The bovine lactoferricin had two tryptophans，so it had higher active than other peptides which contained only one tryptophan. Wide investigations around the tryptophan，the basic amino acid and other aromatic residues were deployed. In this paper，we analyzed and reviewed change of the antibacterial activity after the replacement of the amino acid in the 15-residue bovine lactoferricin，in order to establish the rationale of investigation and development of the bovine lactoferricin.

Key words: lactoferricin, mutant, tryptophan, anti-microbial peptides

TU Qiang, TANG Zhi-Ru, ZHANG You-Ming, YIN Yu-Long. Review on Progress of Bovine Lactoferricin and Its Derivatives Peptides[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(2): 374-378.

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