Chemical Constituents from Melastoma dodecandrum

Abstract

Abstract:

Fifteen compounds were isolated from the ethanol extract of Melastoma dodecandrum. Their structures were elucidated as 4-O-β-D-glucopyranosyl-3,3',4'-tri-O-methylellagic acid (1), quercetin 3-robinobioside (2), 8-C-glucopyranosyl-5,7,3',4'-tetrahydroxyflavone (3), 3-O-β-D-glucopyranosyloxy-4',5,7-trihydroxy flavone (4), 6-C-galactopyranosyl-4',5,7-trihydroxyflavone (5), 3-hydroxy-22(29)-hopen-23-oic acid (6), 2,3-dihydroxy-9(11)-fernen-23-oic acid (7), 3β-sitosterol laminaribioside (8), gingerglycolipid B (9), 3-O-β-D-galactopyranoside-glycerol1-alkanoates (10), daucosterol (11), β-sitosterol (12), octacosanol (13), tetracosanoic acid (14), and tetratriacontane (15) on the basis of spectroscopic analysis and comparison of their spectral data with those of reported. All compounds were isolated from this plant for the first time.

Key words: Melastoma dodecandrum, flavonoids, chemical constituents

YANG Dan, MA Qing-Yun, LIU Yu-Qing, DING Zhong-Tao, ZHOU Jun, ZHAO You-Xing. Chemical Constituents from Melastoma dodecandrum[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2010, 23(6): 940-944.

References

1 Li GX,Song FY,Wu FH,et al.Determination of quercetin in Melastoma dodecandrum by RP-HPLC.West China Journal of Pharmaceutical Sciences,2007,22:455-456.
2 Zhang C,Fang YX.Studies on the Chemical Constituents of Chinese Herb Melastoma dodecandrum.China Journal of Chinese Materia Medica,2003,28:429-431.
3 Zhang C,Fang YX.Studies on the Chemical Constituents of Melastoma dodecandrum（I）.Chinese Traditional and Herbal Drugs, 2003,34:1078-1079.
4 Massiot G,Chen XF,Lavaud C,et al.Saponins from stem bark of Petersianthus macrocarpus.Phytochemistry,1992,
31:3571-3576.
5 Pakulsk G,Budzianowski J.Ellagic acid derivatives and naphthoquinones of Dionaea muscipula from in vitro cultures. Phytochemistry,1996,4:775-778.
6 Khac DD,Tran-Van S,Campos AM,et al.Ellagic compounds from Diplopanax stachyanthus.Phytochemistry,1990,
29:251-256.
7 Wenkert E,Hugo E.Gottlieb.Carbon-13 nuclear magnetic resonance spectroscopy of flavonoid and isoflavonoid compounds. Phytochemistry,1977,16:1811-1816.
8 Barberá O,Sanz JF,Sánchez-Parareda J,et al.Further flavonol glycosides from Anthyllis onobrychioides.Phytochemistry,1986,25: 2361-2365.
9 Webby RF,Markham KR.Flavonol 3-O-triglycosides from Actinidia species.Phytochemistry,1990,2:289-292.
10 Barend CB,Brandt BEV. Flavonoid analogues from Pterocarpus species.Phytochemistry,1987,26:531-535.
11 Kasahara H,Miyazawa M,Kameoka H. O-demethylation of 7,7′-epoxylignans by Aspergillus niger.Phytochemistry,1996,43: 1111-1113.
12 Park SH,Oh SR,Jung KY,et al.Acylated flavonol glycosides with anti-complement activity from Persicaria lapathifolia.Chem. Pharm.Bull,1999,47:1484-1486.
13 Kaneko T,Sakamoto M,Ohtani K,et al.Secoiridoid and flavonoid glycosides from Gonocaryum calleryanum. Phytochemistry,1995,39:115-120.
14 Murakami T.Uber die bestandteile der rhizome von woodwardia orientalis sw.Chem.Pharm Bull,1971,19: 25-30.
15 Lopes A,Villela CT,Kaplan MAC,et al.Moretenolactone, A β-lactone hopanoid from Ficus insipida.Phytochemistry,1993,34, 279-280.
16 Takahashi R,Chiang HC,Aimi N,et al.The structures of retigeric acids A and B from lichens of the Lobaria retigera group. Phytochemistry,1972,11:2039-2045.
17 Iribarren AM,Pomilio AB.Sitosterol 3-O-β- -xylopyranoside from Bauhinia candicans.Phytochemistry,1984,23:2087-2088.
18 Murakami N,Morimoto T,Imamura H,et al.Enzymatic transformation of glyceroglycolipids into sn-1 and sn-2 lysoglyceroglycolipids by use of Rhizopus arrhizus lipase.1991,50:1993-2002.
19 Yoshikawa M,Hatakeyama S,Taniguchi K,et al.Hisashi matda and johji yamahara.Chem Pharm Bull,1992,40:2239-2241.
20 Zhang RL,Sun XC,Li WX,et al.Isolation and idebtification of chemical constituents of Polygonum perfoliatum.Shenyang Yaoke Daxue Xuebao,2008,25:105-107.

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