Synthesis of the Natural Product 5,6,7,3',4'-Pentamethoxyisoflavone

Abstract

Abstract:

The natural product 5,6,7,3',4'-pentamethoxyisoflavone was synthesized by a 5-step synthetic protocol including esterification, Fries transformation, and Vilsmeier-Haack reaction with 3,4-dimethoxyphenylacetic acid and 3,4,5-trimethoxyphenol as the starting materials. The overall yield of the target compound was 76% based on 3,4,5-trimethoxyphenol. The structure of the natural isoflavone 5,6,7,3',4'-pentamethoxyisoflavone was confirmed by NMR and elemental analysis.

Key words: 5,6,7,3',4'-pentamethoxyisoflavone, 3,4,5-trimethoxyphenol, fries transformation, Vilsmeier-Haack reaction, synthesis

REN Wan-Li, CHEN Rui, JIN Ye, ZHANG Tao, LI Hong-Qi. Synthesis of the Natural Product 5,6,7,3',4'-Pentamethoxyisoflavone[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2010, 23(6): 956-960.

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