NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2014, Vol. 26 ›› Issue (8): 1174-1177.

• Article • Previous Articles     Next Articles

Supermolecular Inclusion Property of Methylated-β-cyclodextrin with Chrysophanol and Its in vitro Release Behavior

WU Zhen1, LI Hong2,3, CHEN Gang1, SHI Xuan1, TAN Hong-jun1*   

  1. 1 Chongqing Academy of Chinese Materia Medica,Chongqing 400065 ,China;2Chongqing Institute for Food and Drug Control,Chongqing 401121 ，China; 3 Chongqing Academy of Metrology and Quality Inspection,Chongqing Engineering Research Center of Food Safety,China National Quality Supervision & Inspection Center for Processed Agricultural Products and Condiments,Chongqing 401123 ,China
  • Online:2014-08-30 Published:2014-11-06

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Abstract: To improve the solubility of chrysophanol (Chr),the inclusion complex of Chr-methylated-β-cyclodextrin (M-β-CD) prepared by electromagnetic stirring and spray drying methods (ES) and its supermolecular inclusion property and in vitro release behavior were investigated.Under different temperatures,phase solubility diagrams showed the characteristics of AL type.Under the temperatures of 25, 35 and 45 oC,the supermolecular inclusion constants were 6.56×102, 7.85×102 and 1.09×103 L/mol,respectively.For themodymamic parameters determination, △H0 = 20.09 kJ/mol;△S0 = 121.11 J/(mol·K);△G0= 16.01, 17.21 and 18.42 kJ/mol.The supermolecular complex of M-β-CD with Chr can be formed spontaneously in 1:1 molar ratio.The whole inclusion process was characterized by the entropy driven process.The cumulative release rate of Chr-M-β-CD complex was significant higher than Chr alone and their physical mixture.Chr-M-β-CD complex were sound in physicochemical and release property.It was simple to prepare and can be used as ideal drug delivery system for Chr.

Key words: chrysophanol, methylated-β-cyclodextrin;supermolecular inclusion;in vitro release behavior

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