Optimization of Ultrasonic-assisted Extraction of An Imidazole Alkaloid from Aconitum pendulum Busch by Response Surface Methodology

Abstract

Abstract: In this study,imidazole-2-carboxylic acid butyl ester (ICABE) was ultrasonically extracted from Aconitum pendulum Busch.Three influencing parameters,namely ratio of solvent to solid,extraction time and extraction temperature,were optimized using response surface methodology (RSM).The optimum conditions were as follows: the ratio of solvent to solid was 23 mL/g,extraction temperature was 58 ℃ and extraction time was 51 min.The predicted value of extraction rate of ICABE was 0.081% under the optimum conditions,and the experimental value was 0.079%.The validation test showed that the ultrasonic-assisted extraction process of ICABE was successfully optimized by RSM.

Key words: Aconitum pendulum Busch, imidazole alkaloid, ultrasonic-assisted extraction, response surface methodology

CLC Number:

R284.2

LIU Yong-ling1,2, WANG Ping1,2, CHEN Tao1, CHEN Chen, LI Yu-lin1*. Optimization of Ultrasonic-assisted Extraction of An Imidazole Alkaloid from Aconitum pendulum Busch by Response Surface Methodology[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(8): 1311-1315.

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Optimization of Ultrasonic-assisted Extraction of An Imidazole Alkaloid from Aconitum pendulum Busch by Response Surface Methodology

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