NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2014, Vol. 26 ›› Issue (6): 957-960.

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Effect of Polysaccharide from Spirulina (Arthrospira) platensis of Chad Lake on Immunity and Anti-tumor Activity of S180 Ascites Sarcoma Mice

DU Ling1, HU Rui-ping2*, MU Wen-jing1, ZHAO Fei-yan3, AO Chang-jin3   

  1. 1 College of life science and technology of Inner Mongolia Normal University,Hohhot 010022 ,China; 2 Basic Curriculum Department of Inner Mongolia Medical College,Hohhot 010059,China;3 College of Animal Science and Animal Medicine of Inner Mongolia Agricultural University,Hohhot 010018 ,China
  • Online:2014-06-28 Published:2014-11-12

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Abstract: The objective of this study was to investigate the anti-tumor and immunity regulative activities of polysaccharide from Spirulina (Arthrospira) platensis on S180 ascites sarcoma mice.The sarcoma 180 (S180) was transplanted in the abdominal cavity.The survival quality,tumor appearance of S180 ascites sarcoma mice treated with different doses of polysaccharide from S.(A.) platensis were observed.Immune organ index,concentration of blood serum IL-2 and TNF-α were detected. The results showed that the survival quality were increased,the tumor were inhibited in certain range.The concentrations of IL-2 and TNF-α of S180 ascites sarcoma mice treated with different doses of polysaccharide were significantly increased (P<0.05) with the medium dosage group gave the highest value.Hence,it was concluded that polysaccharide from S.(A.) platensis stimulated the secretion of IL-2,TNF-α of S180 ascites sarcoma mice with lower immune function, enhanced the immune function of S180 ascites sarcoma mice and inhibited S180 ascites sarcoma in mice.

Key words: Spirulina (Arthrospira) platensis, S180 ascites sarcoma, immune organ index, cytokine

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