Abstract: The aim of this study was to obtain Phloracetophenone-4′-beta-Neohesperiodoside though the alkaline hydrolysis of Naringin.The process also included optimization of technic parameters by response surface methodology.The main factors including:solvent,the concentration of potassium hydroxide,temperature,the ratio of solution of potassium hydroxide to naringin.The result showed that the optimal reaction condition was as follow:water as solvent,reaction time for 2 h,the concentration of potassium hydroxide was 15% (w/w),the ratio of solution of potassium hydroxide to naringin was 15(v/w),reaction for 2 h at 100 ℃.The yield of Phloracetophenone-4′-Neohesperiodoside reached 70%.

Key words: naringin, phloracetophenone-4&prime, -neohesperiodoside, response surface methodology, optimization, process parameter