Abstract: In this study,the anti-tumor effects of ginsenoside Rh₄ on mice transplanted tumor were investigated.The mice with sarcoma S₁₈₀ or hepatoma H22 were randomly divided into five groups:negative control group,positive control group,ginsenoside Rh₄ high-dose group,middle-dose group and low-dose group.Ginsenoside Rh₄ was peritoneal injected or intragastric administrated to mice.The implanted mouse model was used to observe the inhibitory effect of ginsenoside Rh₄ on the transplantation tumor’s growth and the immune organ’s weight.After peritoneal injection or intragastric administration of Rh₄ in all dose groups,it can inhibit the growth of S₁₈₀ or H22.Using intragastric administration of Rh₄ at the dose of 4.5 mg/kg,the tumor inhibition rate of bearing sarcoma S₁₈₀ in mice were 47.84% (P<0.01),compared with the control group.The H22 tumor inhibitory rate were 52.72% (P<0.01) by peritoneal injection of Rh₄ at the dose of 10.0 mg/kg.No evident changes were detected in their immune organs in the trial groups.

Key words: transplanted tumor, ginsenoside Rh₄, S₁₈₀, H22, immunologic function